There’s debate on how long can you leave a cat alone in your home while you go on vacation or a business trip. Some say that you shouldn’t leave them alone for more than a day. That’s because some cats get separation anxiety (they want to see you regularly). Another point is that some cats have special needs, such as needing to be fed a certain type of wet food or take medication.
If you only have one cat, leaving him or her alone isn’t a great idea. They need a buddy (at least in my opinion). New kittens need plenty of attention. In those cases and others, I don’t recommend leaving your cats alone for an extended period of time. If those situations apply to your case, you should either hire a professional cat sitter or take the cat to a high quality cat boarding hotel.